Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of adding a leukotriene antagonist or a long-acting beta(2)-agonist in asthmatic patients with the glycine-16 beta(2)-adrenoceptor genotype.

The American journal of medicine - 1 Aug 2000

Lipworth B J, Dempsey O J, Aziz I, Wilson A M

Abstract excerpt

PURPOSE: In the United Kingdom, about 40% of patients with asthma are homozygous for the glycine-16 beta(2)-adrenoceptor polymorphism, which predisposes them to agonist-induced down-regulation and desensitization of the beta(2)-adrenoceptor. We assessed the effects of adding treatment with either...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Inhalation
Share to Adrenergic beta-Agonists
Share to Anti-Asthmatic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bronchial Hyperreactivity

Share to Bronchodilator Agents

Share to Cross-Over Studies

Share to Ethanolamines

Share to Placebos

Source

Identifiers

PMID: 10967152
DOI: 10.1016/s0002-9343(00)00454-x

Genes

FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10967152-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of adding a leukotriene antagonist or a long-acting beta(2)-agonist in asthmatic patients with the glycine-16 beta(2)-adrenoceptor genotype.PMID 10967152Read ↗

Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial.Semantic proximity Read ↗

Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma.Semantic proximity Read ↗

Concomitant occasional use of salbutamol influences bronchoprotective responsiveness afforded by formoterol in patients with the glycine-16 genotype.Semantic proximity Read ↗

Cross tolerance to salbutamol occurs independently of beta2 adrenoceptor genotype-16 in asthmatic patients receiving regular formoterol or salmeterol.Semantic proximity Read ↗

The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol.Semantic proximity Read ↗

Tailored second-line therapy in asthmatic children with the Arg(16) genotype.Semantic proximity Read ↗

Beta 2 Adrenergic Receptor Genetic Polymorphisms in Bronchial Asthma: Relationship to Disease Risk, Severity, and Treatment Response.Semantic proximity Read ↗

Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma.Semantic proximity Read ↗

Polymorphism of the ADRB2 gene and response to inhaled beta- agonists in children with asthma: a meta-analysis.Semantic proximity Read ↗

Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.Semantic proximity Read ↗

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.Semantic proximity Read ↗

Beta2-adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.