Article
Tailored second-line therapy in asthmatic children with the Arg(16) genotype.
Clinical science (London, England : 1979) - 1 Apr 2013
Lipworth Brian J, Basu Kaninika, Donald Helen P, Tavendale Roger, Macgregor Donald F, Ogston Simon A, Palmer Colin N A, Mukhopadhyay Somnath
Abstract excerpt
The Arg(16) β(2) receptor genotype confers increased susceptibility to exacerbations in asthmatic children taking regular LABA (long-acting β(2) agonists). We therefore evaluated using montelukast as an alternative to salmeterol as tailored second-line asthma controller therapy in children expressing this susceptible genotype. A total of 62 persistent asthmatic children with the homozygous Arg16 genotype were...
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