Article
Casein kinase II phosphorylation of the human papillomavirus-18 E7 protein is critical for promoting S-phase entry.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 2000
Chien W M, Parker J N, Schmidt-Grimminger D C, Broker T R, Chow L T
Abstract excerpt
The human papillomavirus type 18 E7 protein subverts the pRb/E2F pathway to promote S-phase reentry by postmitotic, differentiated primary human keratinocytes in support of viral DNA amplification. We prepared a panel of HPV-18 E7 mutations in pRb binding or in casein kinase II (CKII) phosphorylation. Our results showed that the ability of E7 binding to pRb correlated with the activation of DNA polymerase alpha...
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