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Article

Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells.

Oncogene - 24 Aug 2000

Nieborowska-Skorska M, Slupianek A, Skorski T

Abstract excerpt

Our previous study indicated that BCR/ABL SH2 domain and BCR/ABL SH3 domain+SH2 domain complex are required for immediate activation of the phosphatidylinositol-3 kinase PI-3k)--> Akt serine/threonine kinase pathway and of the signal transducer and activator of transcription 5 (STAT5), respectively, in hematopoietic cells. We show here that the defect in activation of PI-3k/Akt by BCR/ABL DeltaSH2 mutant (SH2...

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Share to Cell Line, Transformed
Share to Fusion Proteins, bcr-abl
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Mice, SCID

Share to Precipitin Tests

Share to Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

Share to src Homology Domains

Source

Identifiers

PMID: 10962572
DOI: 10.1038/sj.onc.1203754

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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