Article
The tetramerization domain-independent Ras activation by BCR-ABL oncoprotein in hematopoietic cells.
International journal of oncology - 1 Jun 1998
Tauchi T, Okabe S, Miyazawa K, Ohyashiki K
Abstract excerpt
BCR-ABL is a chimeric oncoprotein that exhibits deregulated tyrosine kinase activity and is implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias. We have previously shown that BCR-ABL activates Ras signaling pathways required for transformation. To elucidate the mech...
Topics
- Adaptor Proteins, Signal Transducing
- Adaptor Proteins, Vesicular Transport
- Animals
- Binding Sites
- Cell Line
- Dimerization
- Female
- Fusion Proteins, bcr-abl
- Gene Expression
- Gene Expression Regulation
- Genes, ras
- Hematopoietic Stem Cells
- Mice
- Mice, Nude
- Mutation
- Phosphorylation
- Protein Structure, Tertiary
- Proteins