Article
Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998
Miyamoto H, Yeh S, Lardy H, Messing E, Chang C
Abstract excerpt
It is known that androst-5-ene-3beta,17beta-diol (Adiol), a precursor of testosterone (T), can activate estrogen target genes. The androgenic activity of Adiol itself, however, is poorly understood. Using a transient transfection assay, we here demonstrate in human prostate cancer cells that Adio...
Topics
- Androgens
- Androstane-3,17-diol
- Androstenediol
- Anilides
- Flutamide
- Humans
- Male
- Mutation
- Nitriles
- Nuclear Receptor Coactivators
- Oncogene Proteins
- Prostatic Neoplasms
- Protein Conformation
- Receptors, Androgen
- Steroids
- Testosterone
- Tosyl Compounds
- Trans-Activators