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Article

Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998

Miyamoto H, Yeh S, Lardy H, Messing E, Chang C

Abstract excerpt

It is known that androst-5-ene-3beta,17beta-diol (Adiol), a precursor of testosterone (T), can activate estrogen target genes. The androgenic activity of Adiol itself, however, is poorly understood. Using a transient transfection assay, we here demonstrate in human prostate cancer cells that Adiol can activate androgen receptor (AR) target genes in the presence of AR, and that AR coactivator ARA70 can further...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9736693
DOI: 10.1073/pnas.95.19.11083
PMCID: PMC21599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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