Article
Concentration-dependent selection of small phenotypic differences in TEM beta-lactamase-mediated antibiotic resistance.
Antimicrobial agents and chemotherapy - 1 Sept 2000
Negri M C, Lipsitch M, Blázquez J, Levin B R, Baquero F
Abstract excerpt
In this paper, the first robust experimental evidence of in vitro and in vivo concentration-dependent selection of low-level antibiotic-resistant genetic variants is described. The work is based on the study of an asymmetric competition assay with pairs of isogenic Escherichia coli strains, differing only (apart from a neutral chromosomal marker) in a single amino acid replacement in a plasmid-mediated TEM-1...
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