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Article

Density-dependent feedback limits the spread of beta-lactamase mutants: experimental observations and population dynamic model.

mBio - 13 Aug 2025

Ruelens Philip, de Ridder Eline, de Visser J Arjan G M, Wortel Meike T

Abstract excerpt

β-Lactamases play an important role in antibiotic-resistant bacterial infections. Understanding the spread of these enzymes may inform the development of better drug therapies. However, this is complicated by the fact that β-lactamases reduce the antibiotic concentration in their environment, thereby altering their own selective advantage via eco-evolutionary feedback. We investigated the effect of such feedback...

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Identifiers

PMID: 40689636
DOI: 10.1128/mbio.01500-25
PMCID: PMC12345237

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