Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Changes in the N- and C-terminal sequences of the murine R7 Gag-tMos protein affect brain lesion induction.

Journal of neurovirology - 1 Aug 2000

Yuen P H, Devroe E, Lim K Y, Wong P K

Abstract excerpt

Our preliminary studies suggested that the novel gag-truncated mos (tmos) open reading frame (ORF) of R7, a spontaneous deletion mutant of Moloney murine sarcoma virus 124 (MoMuSV124), may be responsible for R7's unique ability to induce brain lesions in all R7-injected mice. However, when we replaced the gag-tmos ORF with either the MoMuSV124 or the homologous myeloproliferative sarcoma virus env-mos gene, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Blotting, Northern
Share to Genes, gag

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Mutagenesis, Insertional

Share to Open Reading Frames

Share to RNA, Viral

Source

Identifiers

PMID: 10951557
DOI: 10.3109/13550280009030759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Changes in the N- and C-terminal sequences of the murine R7 Gag-tMos protein affect brain lesion induction.PMID 10951557Read ↗

R7, a spontaneous mutant of Moloney murine sarcoma virus 124 with three direct repeats and an in-frame truncated gag-mos gene, induces brain lesions.Semantic proximity Read ↗

Studies on the pathology, especially brain lesions, induced by R7, a spontaneous mutant of Moloney murine sarcoma virus 124.Semantic proximity Read ↗

A single Glu(62)-to-Lys(62) mutation in the Mos residues of the R7Delta447Gag-tMos protein causes the mutant virus to induce brain lesions.Semantic proximity Read ↗

Unique sequence and lesional tropism of a new variant of neuropathogenic friend murine leukemia virus.Semantic proximity Read ↗

Neurovirulence in mice of soluble receptor-resistant (srr) mutants of mouse hepatitis virus: intensive apoptosis caused by less virulent srr mutant.Semantic proximity Read ↗

A role for dual viral hits in causation of subacute sclerosing panencephalitis.Semantic proximity Read ↗

Overview of Transgenic Mouse Models of Myeloproliferative Neoplasms (MPNs).Semantic proximity Read ↗

The roles of viruses in brain tumor initiation and oncomodulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.