Article
Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Aug 2000
Comuzzie A G, Almasy L, Cole S A, Boss O, Giacobino J P, Muzzin P, Stern M P, MacCluer J W, Blangero J, Hixson J E
Abstract excerpt
OBJECTIVE: To investigate whether the region of chromosome 11 (11q13) containing the genes UCP2 and UCP3 could be excluded for linkage with a variety of obesity-related phenotypes in humans. DESIGN: Exclusion mapping using a variance component approach in extended pedigrees. SUBJECTS: Four-hundred and fifty eight individuals (195 females, 263 males) distributed in 10 Mexican American families of probands randomly...
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