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Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA

11 Dec 2021

Abstract excerpt

Osteosarcoma (OS) is the most common primary bone tumor. Its high mortality rate and metastasis rate seriously threaten human health. Currently, the treatment has reached a plateau, hence we urgently need to explore new therapeutic directions. In this paper, we found that Trio was highly expressed in osteosarcoma than normal tissues and promoted the proliferation, migration, and invasion of osteosarcoma cells....

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PMID: 34893584
DOI: 10.1038/s41419-021-04448-3

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