Article
Independent confirmation of a major locus for obesity on chromosome 10.
The Journal of clinical endocrinology and metabolism - 1 Aug 2000
Hinney A, Ziegler A, Oeffner F, Wedewardt C, Vogel M, Wulftange H, Geller F, Stübing K, Siegfried W, Goldschmidt H P, Remschmidt H, Hebebrand J
Abstract excerpt
Linkage results obtained in genome-wide scans for complex phenotypes require confirmation in independent samples. Recently, linkage of obesity to chromosome 10p12 with a maximal multipoint LOD score of 4.85 was reported upon use of an affected sib-pair approach including nuclear families in which the adult index case had a BMI > or = 40 kg/m2 and at least one further sibling had a BMI > or = 27 kg/m2 (Hager et...
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