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Article

Monosomy 13 Is Associated With the Transition of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma

15 Oct 1999

Abstract excerpt

Chromosomal abnormalities are present in most (if not all) patients with multiple myeloma (MM) and primary plasma cell leukemia (PCL). Furthermore, recent data have shown that numerical chromosomal changes are present in most individuals with monoclonal gammopathy of undetermined significance (MGUS). Epidemiological studies have shown that up to one third of MM may emerge from pre-existing MGUS. To clarify...

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PMID: 10515861
DOI: 10.1182/blood.v94.8.2583.420a05_2583_2589

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Monosomy 13 Is Associated With the Transition of Monoclonal Gammopathy of Undetermined Significance to Multiple MyelomaPMID 10515861Read ↗

Hyperdiploidy Is a Common Finding in Monoclonal Gammopathy of Undetermined Significance and Monosomy 13 Is Restricted to These Hyperdiploid PatientsSemantic proximity Read ↗

Genomic abnormalities in monoclonal gammopathy of undetermined significanceSemantic proximity Read ↗

Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13Semantic proximity Read ↗

A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUSSemantic proximity Read ↗

High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISHSemantic proximity Read ↗

Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentationSemantic proximity Read ↗

Prognostic implications of abnormalities of chromosome 13 and the presence of multiple cytogenetic high-risk abnormalities in newly diagnosed multiple myelomaSemantic proximity Read ↗

Several Cytogenetic Subclones May Be Identified Within Plasma Cells From Patients With Monoclonal Gammopathy of Undetermined Significance, Both at Diagnosis and During the Indolent Course of This ConditionSemantic proximity Read ↗

The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myelomaSemantic proximity Read ↗

Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridizationSemantic proximity Read ↗

Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogeneticsSemantic proximity Read ↗

Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cellsSemantic proximity Read ↗

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