Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Pathogenesis in Sporadic Head and Neck Paraganglioma

1 Aug 2000

Abstract excerpt

HYPOTHESIS: Similar to familial tumors, sporadic head and neck paragangliomas are associated with chromosomal deletions at either 11q13 or 11q22-23. BACKGROUND: Familial paragangliomas are inherited in an autosomal dominant pattern with genomic imprinting of the maternal allele. Genetic studies of familial paragangliomas have localized the causative genetic defect to two separate loci: 11q13.1 and 11q22-23. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal and Paraganglionic Tumors
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetic Syndromes and Imprinting

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10942138
DOI: 10.1097/00005537-200008000-00023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Pathogenesis in Sporadic Head and Neck ParagangliomaPMID 10942138Read ↗

Genetic Analysis in the Diagnosis of Familial ParagangliomasSemantic proximity Read ↗

A gene subject to genomic imprinting and responsible for hereditary paragangliomas maps to chromosome 11q23-qterSemantic proximity Read ↗

Allelotype of head and neck paragangliomas: allelic imbalance is confined to the long arm of chromosome 11, the site of the predisposing locus PGL.Semantic proximity Read ↗

Fine mapping of an imprinted gene for familial nonchromaffin paragangliomas, on chromosome 11q23.Semantic proximity Read ↗

Novel mutations and the emergence of a common mutation in the SDHD gene causing familial paraganglioma.Semantic proximity Read ↗

Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas.Semantic proximity Read ↗

Repositioning the hereditary paraganglioma critical region on chromosome band 11q23.Semantic proximity Read ↗

Familial paraganglioma syndrome: applying genetic screening in otolaryngology.Semantic proximity Read ↗

Chromosome 11 monosomy in conjunction with a mutated SDHD initiation codon in nonfamilial paraganglioma cases.Semantic proximity Read ↗

A Novel Targeted Sequence for Chromosome 11p15.5 Maternal Loss in SDHD-Related Paragangliomas.Semantic proximity Read ↗

Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss.Semantic proximity Read ↗

Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.