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Article

A Novel Targeted Sequence for Chromosome 11p15.5 Maternal Loss in SDHD-Related Paragangliomas.

Genes, chromosomes & cancer - 1 Jan 2026

Lai Huei-Pin, Lee Chen-Hui, Hu Hsuan, Chung An-Ko, Chen Pei-Lung, Yang Wei-Shiung, Wu Wan-Chen

Abstract excerpt

Hereditary paragangliomas (PGLs) caused by germline SDHD pathogenic variants (PVs) exhibit a parent-of-origin effect, with tumors arising almost exclusively when the PV is inherited from the paternal allele. The Hensen model proposes that a cluster of maternally expressed tumor suppressor genes (TSGs) on chromosome 11p15.5 may play a crucial role in SDHD-related PGL tumorigenesis, wherein somatic loss of maternal...

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Share to Chromosomes, Human, Pair 11
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 41556632
DOI: 10.1002/gcc.70107

Genes

SDHD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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A Novel Targeted Sequence for Chromosome 11p15.5 Maternal Loss in SDHD-Related Paragangliomas.PMID 41556632Read ↗

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