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Article

The molecular evolution of signal peptides.

Gene - 8 Aug 2000

Williams E J, Pal C, Hurst L D

Abstract excerpt

Signal peptides direct mature peptides to their appropriate cellular location, after which they are cleaved off. Very many random alternatives can serve the same function. Of all coding sequences, therefore, signal peptides might come closest to being neutrally evolving. Here we consider this issue by examining the molecular evolution of 76 mouse-rat orthologues, each with defined signal peptides. Although they...

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Identifiers

PMID: 10940569
DOI: 10.1016/s0378-1119(00)00233-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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