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Article

Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration

10 Dec 2009

Abstract excerpt

Pathways regulating neuronal vulnerability are poorly understood, yet are central to identifying therapeutic targets for degenerative neurological diseases. Here, we characterize mechanisms underlying neurodegeneration in Niemann-Pick type C (NPC) disease, a lysosomal storage disorder characterized by impaired cholesterol trafficking. To date, the relative contributions of neuronal and glial defects to neuron...

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Cellular transport and secretion
Lysosomal Storage Disorders Research
Parkinson's Disease Mechanisms and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20007718
DOI: 10.1093/hmg/ddp552

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