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Article

Decreased lateral aggregation of a variant recombinant fibrinogen provides insight into the polymerization mechanism.

Biochemistry - 15 Aug 2000

Mullin J L, Gorkun O V, Lord S T

Abstract excerpt

We analyzed the polymerization of BbetaA68T fibrinogen, the recombinant counterpart of fibrinogen Naples, a variant known to have decreased thrombin binding. When polymerized with equal thrombin concentrations, BbetaA68T fibrinogen had a longer lag time and lower rate of lateral aggregation, V(ma...

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Identifiers

PMID: 10933802
DOI: 10.1021/bi000045c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10933802-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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