Article
Incorporation of fibrin molecules containing fibrinopeptide A alters clot ultrastructure and decreases permeability.
British journal of haematology - 1 Jul 2007
Flood Veronica H, Nagaswami Chandrasekaran, Chernysh Irina N, Al-Mondhiry Hamid A, Weisel John W, Farrell David H
Abstract excerpt
Previous studies have shown that a heterozygous mutation in the fibrinogen Aalpha chain gene, which results in an Aalpha R16C substitution, causes fibrinolytic resistance in the fibrin clot. This mutation prevents thrombin cleavage of fibrinopeptide A from mutant Aalpha R16C chains, but not from wild-type Aalpha chains. However, the mechanism underlying the fibrinolytic resistance is unclear. Therefore, this...
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