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Article

Herpes simplex virus 2 (HSV-2) evolves faster in cell culture than HSV-1 by generating greater genetic diversity.

PLoS pathogens - 1 Aug 2021

López-Muñoz Alberto Domingo, Rastrojo Alberto, Martín Rocío, Alcamí Antonio

Abstract excerpt

Herpes simplex virus type 1 and 2 (HSV-1 and HSV-2, respectively) are prevalent human pathogens of clinical relevance that establish long-life latency in the nervous system. They have been considered, along with the Herpesviridae family, to exhibit a low level of genetic diversity during viral replication. However, the high ability shown by these viruses to rapidly evolve under different selective pressures does...

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Identifiers

PMID: 34437654
DOI: 10.1371/journal.ppat.1009541
PMCID: PMC8389525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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