Article
HLA-Gm/kappam interaction in sarcoidosis. Suggestions for a complex genetic structure.
The European respiratory journal - 1 Jul 2000
Martinetti M, Dugoujon J M, Tinelli C, Cipriani A, Cortelazzo A, Salvaneschi L, Casali L, Semenzato G, Cuccia M, Luisetti M
Abstract excerpt
The aetiology of sarcoidosis is still unknown. Environmental exposures are believed to interact with genetic factors in determining the pattern of sarcoidosis presentation, progression and prognosis. The frequency of serological polymorphism of immunoglobulin G heavy chain (Gm) and kappa light chain (kappam) markers in 107 patients with biopsy-proven sarcoidosis and in 227 controls, and their interactions with...
Topics
- Adult
- Epistasis, Genetic
- Female
- Genetic Predisposition to Disease
- HLA Antigens
- Humans
- Immunoglobulin gamma-Chains
- Immunoglobulin kappa-Chains
- Male
- Phenotype
- Polymorphism, Genetic