Article
Gene-environment interactions in sarcoidosis: challenge and opportunity.
Clinics in dermatology - 1 Jan 2000
Culver Daniel A, Newman Lee S, Kavuru Mani S
Abstract excerpt
Susceptibility to most human diseases is polygenic, with complex interactions between functional polymorphisms of single genes governing disease incidence, phenotype, or both. In this context, the contribution of any discrete gene is generally modest for a single individual, but may confer substantial attributable risk on a population level. Environmental exposure can modify the effects of a polymorphism, either...
Topics
- Cluster Analysis
- Environmental Exposure
- Genetic Predisposition to Disease
- Genotype
- HLA Antigens
- Humans
- Risk
- Sarcoidosis