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Article

Structural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin.

The Journal of biological chemistry - 26 Jul 2013

Fernandez Timothy F, Samal Alexandra B, Bedwell Gregory J, Chen Yabing, Saad Jamil S

Abstract excerpt

The extrinsic apoptotic pathway is initiated by cell surface death receptors such as Fas. Engagement of Fas by Fas ligand triggers a conformational change that allows Fas to interact with adaptor protein Fas-associated death domain (FADD) via the death domain, which recruits downstream signaling proteins to form the death-inducing signaling complex (DISC). Previous studies have shown that calmodulin (CaM) is...

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Source

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Identifiers

PMID: 23760276
DOI: 10.1074/jbc.M113.471821
PMCID: PMC3724645

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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