Requirement of sphingolipid alpha-hydroxylation for fungicidal action of syringomycin E.

doi:10.1016/s0014-5793(00)01821-4

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Article

Requirement of sphingolipid alpha-hydroxylation for fungicidal action of syringomycin E.

FEBS letters - 28 Jul 2000

Hama H, Young D A, Radding J A, Ma D, Tang J, Stock S D, Takemoto J Y

Abstract excerpt

Syringomycin E is an antifungal cyclic lipodepsinonapeptide produced by Pseudomonas syringae pv. syringae. To understand the mechanism of action of syringomycin E, a novel resistant Saccharomyces cerevisiae strain, BW7, was isolated and characterized. Lipid analyses revealed that BW7 contained only the hydrophobic subspecies of sphingolipids that are normally minor components in wild type strains. This aberrant...

Topics

Antifungal Agents
Chromatography, High Pressure Liquid
Drug Resistance, Microbial
Fatty Acids
Genetic Complementation Test
Hydroxylation
Mutation
Peptides, Cyclic
Saccharomyces cerevisiae
Sphingolipids

Source

Open in PubMed

Identifiers

PMID: 10922463
DOI: 10.1016/s0014-5793(00)01821-4

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