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Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae

1 Jul 2000

Abstract excerpt

Pentamidine inhibits in vitro splicing of nuclear group I introns from rRNA genes of some pathogenic fungi and is known to inhibit mitochondrial function in yeast. Here we report that pentamidine inhibits the self-splicing of three group I and two group II introns of yeast mitochondria. Comparison of yeast strains with different configurations of mitochondrial introns (12, 5, 4, or 0 introns) revealed that...

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PMID: 10917591
DOI: 10.1017/s1355838200991726

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