Article
Identification of two new Pmp22 mouse mutants using large-scale mutagenesis and a novel rapid mapping strategy.
Human molecular genetics - 22 Jul 2000
Isaacs A M, Davies K E, Hunter A J, Nolan P M, Vizor L, Peters J, Gale D G, Kelsell D P, Latham I D, Chase J M, Fisher E M, Bouzyk M M, Potter A, Masih M, Walsh F S, Sims M A, Doncaster K E, Parsons C A, Martin J, Brown S D, Rastan S, Spurr N K, Gray I C
Abstract excerpt
Mouse mutants have a key role in discerning mammalian gene function and modelling human disease; however, at present mutants exist for only 1-2% of all mouse genes. In order to address this phenotype gap, we have embarked on a genome-wide, phenotype-driven, large-scale N-ethyl-N--nitrosourea (ENU) mutagenesis screen for dominant mutations of clinical and pharmacological interest in the mouse. Here we describe the...
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