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Article

A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity.

Human molecular genetics - 22 Jul 2000

Guan M X, Fischel-Ghodsian N, Attardi G

Abstract excerpt

The A1555 G mutation in mitochondrial 12S rRNA has been found to be associated with non-syndromic deafness and aminoglycoside-induced deafness. The sensitivity to the aminoglycoside paromomycin has been analyzed in lymphoblastoid cell lines derived from five deaf individuals and five hearing individuals from an Arab-Israeli family carrying the A1555G mutation, and three married-in controls from the same family....

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Identifiers

PMID: 10915767
DOI: 10.1093/hmg/9.12.1787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity.PMID 10915767Read ↗

Genetics of aminoglycoside-induced and prelingual non-syndromic mitochondrial hearing impairment: a review.Semantic proximity Read ↗

Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity.Semantic proximity Read ↗

Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity.Semantic proximity Read ↗

Inherited susceptibility to aminoglycoside ototoxicity: genetic heterogeneity and clinical implications.Semantic proximity Read ↗

Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation.Semantic proximity Read ↗

Mitochondrial m.1584A 12S m62A rRNA methylation in families with m.1555A>G associated hearing loss.Semantic proximity Read ↗

Deafness due to A1555G mitochondrial mutation without use of aminoglycoside.Semantic proximity Read ↗

Susceptibility mutations in the mitochondrial small ribosomal RNA gene in aminoglycoside induced deafness.Semantic proximity Read ↗

Mitochondrial tRNAThr G15927A mutation may modulate the phenotypic manifestation of ototoxic 12S rRNA A1555G mutation in four Chinese families.Semantic proximity Read ↗

Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations.Semantic proximity Read ↗

Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation.Semantic proximity Read ↗

Mitochondrial 12S rRNA A827G mutation is involved in the genetic susceptibility to aminoglycoside ototoxicity.Semantic proximity Read ↗

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