Article
Quantitative multiparametric immunophenotyping in acute lymphoblastic leukemia: correlation with specific genotype. I. ETV6/AML1 ALLs identification.
Leukemia - 1 Jul 2000
De Zen L, Orfao A, Cazzaniga G, Masiero L, Cocito M G, Spinelli M, Rivolta A, Biondi A, Zanesco L, Basso G
Abstract excerpt
The t(12;21)(p13;q22) fusion gene is the most frequent genetic lesion described in precursor B cell acute lymphoblastic leukemia (ALL) of childhood occurring in a quarter of cases. This gene rearrangement is associated with a good outcome presenting a high response rate to chemotherapy. In spite of its potential clinical relevance, the t(12;21) translocation usually goes undetected with conventional cytogenetic...
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