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Article

Identification of the in vivo role of a viral bcl-2.

The Journal of experimental medicine - 1 Apr 2002

Gangappa Shivaprakash, van Dyk Linda F, Jewett Travis J, Speck Samuel H, Virgin Herbert W

Abstract excerpt

Many gamma-herpesviruses encode candidate oncogenes including homologues of host bcl-2 and cyclin proteins (v-bcl-2, v-cyclin), but the physiologic roles of these genes during infection are not known. We show for the first time in any virus system the physiologic role of v-bcl-2. A gamma-herpesvirus v-bcl-2 was essential for efficient ex vivo reactivation from latent infection, and for both persistent replication...

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Identifiers

PMID: 11927636
DOI: 10.1084/jem.20011825
PMCID: PMC2193719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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