Article
Coupling photoisomerization of retinal to directional transport in bacteriorhodopsin.
Journal of molecular biology - 28 Jul 2000
Luecke H, Schobert B, Cartailler J P, Richter H T, Rosengarth A, Needleman R, Lanyi J K
Abstract excerpt
In order to understand how isomerization of the retinal drives unidirectional transmembrane ion transport in bacteriorhodopsin, we determined the atomic structures of the BR state and M photointermediate of the E204Q mutant, to 1.7 and 1.8 A resolution, respectively. Comparison of this M, in which proton release to the extracellular surface is blocked, with the previously determined M in the D96N mutant indicates...
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