Article
Modeling evolution at the protein level using an adjustable amino acid fitness model.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2000
Dimmic M W, Mindell D P, Goldstein R A
Abstract excerpt
An adjustable fitness model for amino acid site substitutions is investigated. This model, a generalization of previously developed evolutionary models, has several distinguishing characteristics: it separately accounts for the processes of mutation and substitution, allows for heterogeneity among substitution rates and among evolutionary constraints, and does not make any prior assumptions about which sites or...
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