Article
Genetic polymorphism at the CLOCK gene locus and major depression.
American journal of medical genetics - 12 Jun 2000
Desan P H, Oren D A, Malison R, Price L H, Rosenbaum J, Smoller J, Charney D S, Gelernter J
Abstract excerpt
Genetic analysis in both mouse and Drosophila has indicated that the product of the CLOCK gene is an essential component of a circadian rhythm timing system. A single nucleotide polymorphism (SNP), T3111C, in the 3' flanking region of the human CLOCK gene has been identified. Homozygotes or heterozygotes for the 3111C allele have been reported to have higher mean scores on a measure of evening preference for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.