Article
Biological activities of recombinant chicken leptin C4S analog compared with unmodified leptins.
American journal of physiology. Endocrinology and metabolism - 1 Jul 2000
Dridi S, Raver N, Gussakovsky E E, Derouet M, Picard M, Gertler A, Taouis M
Abstract excerpt
The chicken leptin sequence, in contrast to mammalian leptins, contains an unpaired Cys at position 3 of the original cDNA (AF012727). The presence of an extra Cys may confer a different structure and affect the leptin's biological activity. To address this, we studied the effects of wild-type and mutated (C4S) chicken leptins in vitro and in vivo and compared them with mammalian leptin prepared from ovine leptin...
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