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Article

KlRHO1 and KlPKC1 are essential for cell integrity signalling in Kluyveromyces lactis.

Microbiology (Reading, England) - 1 Sept 2006

Rodicio Rosaura, Koch Sabrina, Schmitz Hans-Peter, Heinisch Jürgen J

Abstract excerpt

Cell integrity in yeasts is ensured by a rigid cell wall whose synthesis is triggered by a MAP kinase-mediated signal-transduction cascade. Upstream regulatory components of this pathway in Saccharomyces cerevisiae involve a single protein kinase C, which is regulated by interaction with the small GTPase Rho1. Here, two genes were isolated which encode these proteins from Kluyveromyces lactis (KlPKC1 and KlRHO1)....

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PMID: 16946259
DOI: 10.1099/mic.0.29105-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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KlRHO1 and KlPKC1 are essential for cell integrity signalling in Kluyveromyces lactis.PMID 16946259Read ↗

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Comparative genetic and physiological studies of the MAP kinase Mpk1p from Kluyveromyces lactis and Saccharomyces cerevisiae.Semantic proximity Read ↗

Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.Semantic proximity Read ↗

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PGK1, the gene encoding the glycolitic enzyme phosphoglycerate kinase, acts as a multicopy suppressor of apoptotic phenotypes in S. cerevisiae.Semantic proximity Read ↗

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Saccharomyces cerevisiae YCRO17c/CWH43 encodes a putative sensor/transporter protein upstream of the BCK2 branch of the PKC1-dependent cell wall integrity pathway.Semantic proximity Read ↗

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The Kluyveromyces lactis equivalent of casein kinase I is required for the transcription of the gene encoding the low-affinity glucose permease.Semantic proximity Read ↗

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