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Article

A novel X-linked combined immunodeficiency disease.

The Journal of clinical investigation - 1 Nov 1990

Brooks E G, Schmalstieg F C, Wirt D P, Rosenblatt H M, Adkins L T, Lookingbill D P, Rudloff H E, Rakusan T A, Goldman A S

Abstract excerpt

A novel X-linked combined immunodeficiency disease was found in five living males in an extended family in the United States. The age of the affected males ranged from 2.5 to 34 yr. The most prominent clinical abnormalities were a paucity of lymphoid tissue; recurrent sinusitis, otitis media, bronchitis, and pneumonia; severe varicella; and chronic papillomavirus infections. The principal immunologic features of...

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Identifiers

PMID: 2243135
DOI: 10.1172/JCI114884
PMCID: PMC296912

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