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Article

Repeat polymorphisms within gene regions: phenotypic and evolutionary implications.

American journal of human genetics - 1 Aug 2000

Wren J D, Forgacs E, Fondon J W, Pertsemlidis A, Cheng S Y, Gallardo T, Williams R S, Shohet R V, Minna J D, Garner H R

Abstract excerpt

We have developed an algorithm that predicted 11,265 potentially polymorphic tandem repeats within transcribed sequences. We estimate that 22% (2,207/9,717) of the annotated clusters within UniGene contain at least one potentially polymorphic locus. Our predictions were tested by allelotyping a panel of approximately 30 individuals for 5% of these regions, confirming polymorphism for more than half the loci...

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Identifiers

PMID: 10889045
DOI: 10.1086/303013
PMCID: PMC1287183

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