Article

The Genetic and Evolutionary Landscape of Pentanucleotide Tandem Repeats in Human Genomes

2025-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Tandem repeats are a class of genetic variation characterized by repetitions of DNA motifs of diverse sequences and lengths. Pentameric motifs, in particular, do not align with the protein-coding reading frames, often confining them to the less extensively studied non-coding portion of the genome. Intronic pentanucleotide tandem repeats are associated with 11 neurological disorders. Their pathog...

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Literature Corpus work: d7178446-83f2-57bb-8463-a9eb28f8cb0d
DOI: 10.1101/2025.05.27.656002

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