Systemic polyomavirus genome increase and dissemination of capsid-defective genomes in mammary gland tumor-bearing mice.

doi:10.1128/jvi.74.15.6975-6983.2000

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Article

Systemic polyomavirus genome increase and dissemination of capsid-defective genomes in mammary gland tumor-bearing mice.

Journal of virology - 1 Aug 2000

Wirth J J, Chen L, Fluck M M

Abstract excerpt

BALB/c mice that developed tumors 7 to 8 months following neonatal infection by polyomavirus (PYV) wild-type strain A2 were characterized with respect to the abundance and integrity of the viral genome in the tumors and in 12 nontumorous organs. These patterns were compared to those found in tumor-free mice infected in parallel. Six mice were analyzed in detail including four sibling females with mammary gland...

Topics

Animals
Animals, Newborn
Blotting, Northern
Capsid
DNA, Viral
Female
Genome, Viral
Kidney
Male
Mammary Glands, Animal
Mammary Neoplasms, Experimental
Mice
Mice, Inbred BALB C
Mutation
Polyomavirus
Polyomavirus Infections
RNA, Viral
Restriction Mapping

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Identifiers

PMID: 10888636
DOI: 10.1128/jvi.74.15.6975-6983.2000
PMCID: PMC112214

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