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Article

Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.

American journal of respiratory cell and molecular biology - 1 Jun 2011

Cowburn Andrew S, Summers Charlotte, Dunmore Benjamin J, Farahi Neda, Hayhoe Richard P, Print Cristin G, Cook Simon J, Chilvers Edwin R

Abstract excerpt

Neutrophil apoptosis is essential for the resolution of inflammation but is delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis through transcriptional regulation of anti-death (Bcl-X(L), Mcl-1, Bcl2A1) or BH3-only (Bim, Bid, Puma) Bcl2-family proteins. We report that granulocyte/macrophage colony-stimulating factor...

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Identifiers

PMID: 20705940
DOI: 10.1165/rcmb.2010-0101OC
PMCID: PMC4373550

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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