Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations.

Oncology reports - 1 Apr 2005

Misiewicz Irena, Kozar Agata, Skupinska Katarzyna, Kowalska Elzbieta, Lubinski Jan, Kasprzycka-Guttman Teresa

Abstract excerpt

The important aspect of sulforaphane (SFN) chemopreventive activity is its ability to induce cell growth inhibition and apoptosis. In this study, the effect of SFN on lymphoblastoid cells derived from people carrying four different germ-line mutations in BRCA1 gene was tested and compared to the effect of SFN on wild-type cells. The mutations studied were C61G, 3819del5, 4153delA and 5382INSC. Changes in cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticarcinogenic Agents
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Membranes

Share to Isothiocyanates

Share to JNK Mitogen-Activated Protein Kinases

Share to Membrane Potentials

Share to Phosphatidylserines

Share to S Phase

Source

Identifiers

PMID: 15756439

Genes

SFN
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations.PMID 15756439Read ↗

Sulforaphane inhibits growth of phenotypically different breast cancer cells.Semantic proximity Read ↗

Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations.Semantic proximity Read ↗

Selective Growth Inhibition of Human Leukemia and Human Lymphoblastoid Cells by Resveratrol via Cell Cycle Arrest and Apoptosis InductionSemantic proximity Read ↗

Evaluation of Sphinganine and Sphingosine as Human Breast Cancer Chemotherapeutic and Chemopreventive AgentsSemantic proximity Read ↗

SN-38 Induces Cell Cycle Arrest and Apoptosis in Human Testicular CancerSemantic proximity Read ↗

Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cellsSemantic proximity Read ↗

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer CellsSemantic proximity Read ↗

Sulforaphane mitigates genotoxicity induced by radiation and anticancer drugs in human lymphocytes.Semantic proximity Read ↗

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosisSemantic proximity Read ↗

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug.Semantic proximity Read ↗

The activity of Selol in multidrug-resistant and sensitive human leukemia cells.Semantic proximity Read ↗

Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.