Cancer population genetics and tumour prevention: an unfulfilled paradigm.

Abstract excerpt

The molecular approach to cancer has identified specific abnormalities that contribute to malignant pathogenesis in an aetiological manner and define individuals who are at higher risk for specific malignancies. Studies of cancer distribution in families suggest that 15-20% of all malignancies may have a significant germ line hereditable mutation that directly or indirectly contributes to tumour development....

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