Article
Cancer Genetics and Implications for Clinical Management.
The Surgical clinics of North America - 1 Oct 2015
Jamieson Nigel B, Chang David K, Biankin Andrew V
Abstract excerpt
There is now compelling evidence that the molecular heterogeneity of cancer is associated with disparate phenotypes with variable outcomes and therapeutic responsiveness to therapy in histologically indistinguishable cancers. This diversity may explain why conventional clinical trial designs have mostly failed to show efficacy when patients are enrolled in an unselected fashion. Knowledge of the molecular...
Topics
- Antineoplastic Agents
- Biomarkers, Tumor
- Drug Resistance, Neoplasm
- Genomics
- Genotype
- Humans
- Mutation
- Neoplasms
- Phenotype
- Precision Medicine