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Article

An integrated framework for the inference of viral population history from reconstructed genealogies.

Genetics - 1 Jul 2000

Pybus O G, Rambaut A, Harvey P H

Abstract excerpt

We describe a unified set of methods for the inference of demographic history using genealogies reconstructed from gene sequence data. We introduce the skyline plot, a graphical, nonparametric estimate of demographic history. We discuss both maximum-likelihood parameter estimation and demographic hypothesis testing. Simulations are carried out to investigate the statistical properties of maximum-likelihood...

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Identifiers

PMID: 10880500
DOI: 10.1093/genetics/155.3.1429
PMCID: PMC1461136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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