Article
Detection by denaturant gradient gel electrophoresis of tumor-specific mutations in biopsies and relative bronchoalveolar lavage fluid from resectable non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2000
Ferretti G, Curigliano G, Pastorino U, Cittadini A, Flamini G, Calabrò M G, De Pas T, Orlando L, Mandalà M, Colleoni M, Spaggiari L, Granone P L, Pagliari G, de Braud F, Fazio N, Goldhirsch A
Abstract excerpt
A PCR-denaturant gradient gel electrophoresis (DGGE) method was developed for the detection of p53 and K-ras mutations in primary operable tumors and paired BAL samples of non-small cell lung cancer. Among 36 patients, 9 showed p53 exon V mutations in biopsies and in three paired bronchoalveolar...
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