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Article

The NH2-terminal region of focal adhesion kinase reconstitutes high affinity IgE receptor-induced secretion in mast cells.

The Journal of biological chemistry - 8 Sept 2000

Vial D, Okazaki H, Siraganian R P

Abstract excerpt

Focal adhesion kinase (FAK) is tyrosine-phosphorylated by adherence of cells and also by FcepsilonRI aggregation in RBL-2H3 mast cells. Using phosphorylation site-specific antibodies, we observed that FcepsilonRI activation in these cells led to an increase in FAK phosphorylation at the same tyrosine residues that are phosphorylated by integrin-induced activation. Previous studies in the 3B6 line, a FAK-deficient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Protein-Tyrosine Kinases

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Source

Identifiers

PMID: 10862765
DOI: 10.1074/jbc.M002842200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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