Evidence for major genes influencing pulmonary function in the NHLBI family heart study.

doi:10.1002/1098-2272(200007)19:1<81::AID-GEPI6>3.0.CO;2-8

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Article

Evidence for major genes influencing pulmonary function in the NHLBI family heart study.

Genetic epidemiology - 1 Jul 2000

Wilk J B, Djousse L, Arnett D K, Rich S S, Province M A, Hunt S C, Crapo R O, Higgins M, Myers R H

Abstract excerpt

Segregation analysis was performed on the pulmonary measures forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the ratio of FEV1/FVC in 455 randomly ascertained families from the NHLBI Family Heart Study (FHS). Gender specific standardized residuals were used as the phenotypic variable in both familial correlation and segregation analyses. These residuals represented adjustments for...

Topics

Anthropometry
Chi-Square Distribution
Family
Female
Forced Expiratory Volume
Humans
Lung Diseases
Male
Models, Genetic
Phenotype
Regression Analysis
Smoking
Spirometry
Vital Capacity

Source

Open in PubMed

Identifiers

PMID: 10861898
DOI: 10.1002/1098-2272(200007)19:1<81::AID-GEPI6>3.0.CO;2-8

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