Environmental factors can confound identification of a major gene effect: results from a segregation analysis of a simulated population of lung cancer families.

Abstract excerpt

Proper control of environmental factors can be crucial to the identification of genes that influence susceptibility to a complex trait, especially for a trait such as lung cancer, for which the environmental factor (smoking) accounts for a significant etiologic fraction of the disease. An earlier segregation analysis of 337 Louisiana families, which incorporated direct measure of tobacco consumption, provided...

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