Article
Environmental factors can confound identification of a major gene effect: results from a segregation analysis of a simulated population of lung cancer families.
Genetic epidemiology - 1 Jan 1998
Sellers T A, Weaver T W, Phillips B, Altmann M, Rich S S
Abstract excerpt
Proper control of environmental factors can be crucial to the identification of genes that influence susceptibility to a complex trait, especially for a trait such as lung cancer, for which the environmental factor (smoking) accounts for a significant etiologic fraction of the disease. An earlier...
Topics
- Computer Simulation
- Confounding Factors, Epidemiologic
- Environmental Health
- Family Health
- Female
- Genes, Dominant
- Genes, Recessive
- Genetic Predisposition to Disease
- Genetics, Population
- Humans
- Lung Neoplasms
- Male
- Meiosis
- Models, Genetic
- Risk Factors
- Smoking
- United States