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Article

Glomerular expression of type IV collagen chains in normal and X-linked Alport syndrome kidneys.

The American journal of pathology - 1 Jun 2000

Heidet L, Cai Y, Guicharnaud L, Antignac C, Gubler M C

Abstract excerpt

Alport syndrome is an inherited nephropathy characterized by alterations of the glomerular basement membrane because of mutations in type IV collagen genes. COL4A5 mutations, causing X-linked Alport syndrome, frequently result in the loss of the alpha5 chains of type IV collagen in basement membranes. This is associated with the absence of the alpha3(IV) and alpha4(IV) chains and increased amounts of alpha1(IV)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Glomerular Mesangium

Share to Kidney Glomerulus

Share to Nephritis, Hereditary

Share to Renal Circulation

Source

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Identifiers

PMID: 10854213
DOI: 10.1016/S0002-9440(10)65063-8
PMCID: PMC1850092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glomerular expression of type IV collagen chains in normal and X-linked Alport syndrome kidneys.PMID 10854213Read ↗

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Identification of a distinct type IV collagen alpha chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome.Semantic proximity Read ↗

Autosomal recessive Alport syndrome: immunohistochemical study of type IV collagen chain distribution.Semantic proximity Read ↗

Deletions in the COL4A5 collagen gene in X-linked Alport syndrome. Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression.Semantic proximity Read ↗

Comparative distribution of the alpha 1(IV), alpha 5(IV), and alpha 6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients.Semantic proximity Read ↗

Glomerular pathology in Alport syndrome: a molecular perspective.Semantic proximity Read ↗

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Quantitative analysis of glomerular type IV collagen alpha3-5 chain expression in children with thin basement membrane disease.Semantic proximity Read ↗

Quantitative analysis of type IV collagen subchains in the glomerular basement membrane of patients with Alport syndrome with confocal microscopy.Semantic proximity Read ↗

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