Article
Quantitative analysis of glomerular type IV collagen alpha3-5 chain expression in children with thin basement membrane disease.
Nephron - 1 Oct 2002
Ueda Taku, Nakajima Mitsuru, Akazawa Hideki, Maruhashi Yoshiyuki, Shimoyama Hironobu, Sakagami Yoshitugu, Takagawa Ken, Kamitsuji Hidekazu, Naito Ichiro, Sado Yoshikazu, Yoshioka Akira
Abstract excerpt
Thin basement membrane disease (TBMD) and Alport syndrome, two forms of childhood nephritis, have generally been considered to be hereditary diseases. In Alport syndrome, several reports have demonstrated pathogenic mutations of the genes encoding type IV collagen alpha3, 4 and/or 5 chain [alpha3, 4 and/or 5(IV)]. Previous immunohistochemical studies indicated that these antigens were absent from the glomerular...
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