Article
Quantitative analysis of type IV collagen subchains in the glomerular basement membrane of patients with Alport syndrome with confocal microscopy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jul 2006
Su Jian, Liu Zhi-Hong, Zeng Cai-Hong, Wei-Gong, Chen Hui-Ping, Li Lei-Shi
Abstract excerpt
BACKGROUND: Alport syndrome (AS) is an inherited nephropathy characterized by glomerular basement membrane (GBM) abnormalities due to mutations in the type IV collagen genes. Through immunofluorescence analysis, the absence of alpha3(IV), alpha4(IV) and alpha5(IV) chains within the GBM has been shown in the majority of AS cases. In some atypical AS cases, however, staining of the GBM with antibodies against the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.